Conception Can Only Take Place In an Alkaline Environment!

Posted by luputtenan3 on Saturday, March 3, 2012


  • Dr. Young, I just wanted to send a follow-up message regarding the issue I contacted you about last time. Back in 2011, both my wife and I were feeling devastated by the news from her doctor that her FSH was at "pre-menopausal levels" (Day-3 FSH of 33), and the doctor implied that she would not be able to get pregnant. I refused to believe that and started taking my wife to Jamba Juice to drink a 1 oz shot of fresh liquid wheatgrass daily. I also contacted you to ask for your advice. Your suggestion was to follow the pH Miracle lifestyle and diet as outlined in Chapter 11 of your book (pH Miracle Revised). We bought the book, and signed up for the group cleanse (led by Caroline). We did the cleanse for 7 days and after transitioning back to solid foods, we kept taking the Doc Brocs and salts, etc.

    Today, I am so happy to give you the wonderful news that my wife is pregnant! We are both feeling so overwhelmed and happy at this amazing and miraculous news, especially when the doctors had basically told us there was no chance. I want to express our deepest gratitude to you for your work and for your message of healing, and in responding to my request for advice and help at a time when we were feeling so devastated.

    I wanted to confirm, if there is anything that my wife should stop taking now that she is pregnant. This is what we have been taking on a daily basis:

    Doc Brocs (3 times a day)
    pHruits and pHoliage (once a day)
    puripHy drops in the water
    chloropHeal (15 drops in water)
    pHour salts (once a day)
    Terra pHirma (Montmorillonite Clay, half a scoop once a day)
    Vitamin D3 (10,000IU once a day)
    Omega 3-6-9 Essential Oil Blend

    Is there anything from above that she should stop, or modify the dosage?

    Thank you so much. I feel so grateful and humble. This will be our first child and it means so much, especially after everything we have gone through. May God bless you and your family, and give you every assistance in your life's mission.

    Best Regards,
    J


    Dear J,


    Congratulations to you and your wife on your pregnancy. All things are possible to those who believe. Miracles happen when you restore the alkaline design of the body with an alkaline lifestyle and diet. The pH Miracle Lifestyle and Diet prepares both men and women with an alkaline body for the potential of conception. Conception can only take place in an alkaline environment. Dietary and metabolic acid destroys the egg and sperm. Continue with the alkaline program during pregnancy. When you are alkaline you prevent many of the negative symptoms of pregnancy such as morning sickness, low energy and excess weight gain.


    Once again congratulations!


    Dr. Robert O. Young

More aboutConception Can Only Take Place In an Alkaline Environment!

Global Warming and Body Warming Are Caused By Acid

Posted by luputtenan3 on Friday, March 2, 2012


The above picture is the acidification of blood which
causes degeneration of the red and white blood cells,
internal blood clotting and chaining of the red blood
cells. This condition of the blood leads to light headedness, dizziness,
cold hands, cold feet, forgetfulness, muddle thinking or
brain fog, stroke, heart attack, tumor formation and
internal bleeding, just to name a few

I have been studying the acid/alkaline conditions of the
blood for over twenty-five years and have determined
that all sickness and dis-ease or body warming is caused
by the over-acidification of the blood and tissues due to an inverted
way of living, eating and thinking.

Scientists have been studying the acid/alkaline
conditions at the bottom of the Mediterranean Sea.

Natural carbon dioxide vents on the sea floor are
showing scientists how carbon emissions will affect
marine life.

Dissolved CO2 makes water more acidic, and around
the vents, researchers saw a fall in species numbers,
and snails with their shells disintegrating because of
the increase of acid C02.

Writing in the journal Nature, the UK scientists
suggest these impacts are likely to be seen across
the world as CO2 levels rise in the atmosphere.

Some of the extra CO2 emitted enters the oceans,
acidifying waters globally.

The only way of reducing the impact of ocean
acidification is the urgent reduction in CO2
emissions.

"These same principals of acidification of the
ocean also apply to the acidification of our
body and the causative reason for the increase
in cancer, heart disease, diabetes and all other
degenerative diseases," states Dr. Robert O. Young,
a research scientist at the pH Miracle Living Center.

"Studies have shown that the seas have become more
acidic since the industrial revolution," states
Carol Turley. of the Plymouth Marine Laboratory.

Research leader Jason Hall-Spencer from the University
of Plymouth said that atmospheric CO2 concentrations
were now so high that even a sharp fall in emissions
would not prevent some further acidification of the
ocean.

"It's clear that marine food webs as we know them are
going to alter, and biodiversity will decrease," he
told BBC News.

"Those impacts are inevitable because acidification is
inevitable - we've started it, and we can't stop it."

Corals construct their external skeletons by extracting
dissolved calcium carbonate from seawater and using it
to form two minerals, calcite and aragonite. Molluscs
use the same process to make their shells.

As water becomes more acidic, the concentration of
calcium carbonate falls. Eventually there is so
little that shells or skeletons cannot form.

The oceans are thought to have absorbed about half
of the extra CO2 put into the atmosphere in the
industrial age. This has lowered its pH by 0.1
pH is the measure of acidity and alkalinity.

The vast majority of liquids lie between pH 0
(highly acidic) and pH 14 (highly alkaline); 7
is the midpoint of the pH scale. Seawater is
mildly alkaline with a "natural" pH of about
8.3.

The IPCC forecasts that ocean pH will fall by
"between 0.14 and 0.35 units over the 21st Century,
adding to the present decrease of 0.1 units since
pre-industrial times."

Around the vents which Dr Hall-Spencer's team
investigated, in the Mediterranean Sea near the
Italian coast, CO2 bubbling into the water forms
a sort of natural laboratory for studying the
impacts of acidified water on marine life.

Globally, the seas now have an average pH of about
8.1 - down about 0.2 since the dawn of the
industrial age.

Around the vents, it fell as low as 7.4 in some places.
But even at 7.8 to 7.9, the number of species present
was 30% down compared with neighboring areas.

Coral was absent, and species of algae that use
calcium carbonate were displaced in favour of
species that do not use it.

Snails were seen with their shells dissolving.
There were no snails at all in zones with a
pH of 7.4.

Meanwhile, sea grasses thrived, perhaps because
they benefit from the extra carbon in the water.

These observations confirm that some of the
processes seen in laboratory experiments and
some of the predictions made by computer models
of ocean ecosystems do also happen in the real world.

"I can't count the number of times that scientific
talks end with 'responses have not yet been
documented in the field'," said Elliott Norse,
president of the Marine Conservation Biology
Institute (MCBI).

"This paper puts that to rest for several
ecologically important marine groups."

The Intergovernmental Panel on Climate Change (IPCC)
suggests that without measures to restrain carbon
dioxide emissions, ocean pH is likely to fall to about
7.8 by 2100.

This suggests that some of the impacts seen
around the Mediterranean vents might be widespread.

"I think we will see the same pattern in other parts
of the world, because we're talking about keystone
species such as mussels and limpets and barnacles
being lost as pH drops," said Dr Hall-Spencer.

The IPCC suggests that some areas, notably the
Southern Ocean, might feel the impacts at lower
concentrations of CO2.

Last month, scientists reported that water with
CO2 levels high enough to be "corrosive" to marine
life was rising up off the western US coast.

Bottom water naturally contains more CO2 than at
shallower depths. This scientific team argues
that human emissions have pushed these levels
even higher, contributing to pH values as low 7.5
in waters heavily used by US fishermen.

"If [pH 7.8] is a universal 'tipping point', then
it indicates that sections of the western coast
waters off North America may have passed this
threshold during periods when this upwelling of
waters high in CO2 occurs," commented Carol Turley
from Plymouth Marine Laboratory (PML), who was not
involved in the Mediterranean Sea study (PML is
not affiliated with Plymouth University).

Organisms such as coral are also damaged by rising
temperatures, and studies are ongoing into the
combined effect of a warming and acidifying ocean.

Seagrasses were among the few beneficiaries of
more acid waters. There is much to learn. And
during the coming week, scientists will announce
the inauguration of the European Project on Ocean
Acidification (Epoca), a four-year, 16m euro (£12.5m)
initiative aiming to find some answers.

Studying the impacts may prove easier than doing
anything about them.

"The reason that the oceans are becoming more acidic
is because of the CO2 emissions that we are producing
from burning fossil fuels," observed Dr Turley.

"Add CO2 to seawater and you get carbonic acid;
it's simple chemistry, and therefore certain.

"This means that the only way of reducing the future
impact of ocean acidification is the urgent,
substantial reduction in CO2 emissions."

According to Dr. Young, "ocean acidification is
the macro view of our oceans becoming sick and tired
and the primary causative factor in global warming.
The death and extinction of marine life is the result
of this acidification which can be prevented with
alkalizing measures."

"Body acidification is the micro view of our
internal oceans becoming sick and tired and the
primary causative factor in body warming or
all sickness and dis-ease. The death and extinction
of the human race will be a result of an over-
acidification of the blood and tissues due to an
inverted way of living, eating and thinking. This
is what scientist have determined happened to the
extinction of the Mayan Race. We can prevent all
sickness and dis-ease (cancer, heart dis-ease,
diabetes, etc.) and the potential extinction of
the human race by learning how to maintain the
alkaline design of our body. These life changing
and life saving principals are taught in our
pH Miracle books, DVD's and CD's."

To learn how to maintain the alkaline design
of the body and prevent sickness and
dis-ease go to:

http://www.phmiracleliving.com/books.htm
http://www.phmiracleliving.com/audios.htm
http://www.phmiracleliving.com/videos.htm
More aboutGlobal Warming and Body Warming Are Caused By Acid

The Growing Acidity of Our Oceans is a Threat to ALL Life on Earth!

Posted by luputtenan3

The growing acidity in our ocean waters is a threat to mankind and will wipe out coral and many species of fish and other sea life if nothing is done soon.

Extra carbon dioxide in the air caused by the burning of fossil fuels is not only spurring climate change, but is making the oceans more acidic and endangering the marine life that helps to remove carbon dioxide from the earth's atmosphere.

Marine scientists have become so alarmed that special briefings have been held for goverment departments. Carol Turley, head of science at Plymouth Marine Laboratory in England, warnedof a "potentially gigantic" problem for the world.

"It is very urgent to warn people what is happening," she said. "Many of the species we rely on to eat, like cod, will disappear. In cartoon form, you could say people should prepare to change their tastes from cod and chips to jellyfish and chips. The whole composition of life in the oceans will change."

Jerry Blackford, another of the authors of a paper presented to a climate change conference in Exeter, England, has modeled the effect on the oceans. He said: "Some scientists are saying that in 35 years all the coral reefs in the world could be dead - it could be less or more. Put it this way, my children may never get the opportunity to go snorkeling on a living reef. Certainly, my grandchildren won't."

Although the phenomenon is caused by the excess acidity of carbon dioxide in the atmosphere, it is not a "global warming" problem. It is more serious then that!

A simple chemical reaction between the acidic air and the alkaline sea starts the chemical and electrical attraction. With the sea being alkaline and the air being acidic, it pulls the carbon dioxide into its watery body causing an acidic decline in the pH and the potential death of the oceans! The oceans of the world are becoming cancerous!

Carbon dioxide mixed with water produces carbonic acid making the oceans more and more acidic and increasingly sick. For example, it takes thirty parts of alkalinity in the form of sodium bicarbonate to buffer or neutralize one part or one molecule of carbonic acid in order to maintain a pH of 8.2 - the healthy pH of our oceans. Thus, the chemistry to buffer carbonic acid in the oceans is a thirty to one ratio. This means thatit is going to be virtually impossible to reverse this catastrophic situation unless we do something about decreasing the emissions of carbon dioxide in the atmosphere--and do it NOW!

Current scientists, like doctors, have not been looking at this potential problem because they have assumed the chemical composition of the sea is constant just like our blood pH. This is not case for the oceans or our blood. The oceans and our blood are constantly trying to maintain their alkalinity at the expense of the coral for the ocean and the bones for our blood.

Scientist are just now seeing the huge problem with the oceans becoming more and more acidic. They are beginning to see that our oceans are beginning to die.

And when the oceans begin to die, we begin to die - risking human extinction!

The oceans vital role in limiting carbon dioxide levels in theair is now being reassessed by scientists aroung the world. Plankton are as important as plants and trees in the take-up of carbon dioxide.

We estimate that about half the 800 billion tons of carbondioxide put into the atmoshere by mankind since the startof the industrial revolution has been soaked up by the sea.

Much of the carbon dioxide poison is fixed in the shells of creatures called coccolithphores, the tiny plankton whose bodies make up the white cliffs of Dover in England. They live on the ocean surface in trillions and when they die, their shells sink to the bottom of the ocean taking the carbon dioxide with them. They could not survive in a more acidic sea and their removal of carbon dioxide from the atmosphere would stop. These creatures are part of the survival of the human race. The oceans give us a sustainable atmosphere by taking out the carbon dioxide.

They are the lungs of the planet. People have not awakened to the potential impact that their removal will cause! The acidity of any liquid is measured on the pH scalefrom 1 to 14, with 7 being the midpoint. The higherthe number, the more alkaline. The oceans have previously been recorded at an 8.2 pH reading which is approximately 10 times more alkaline then human or animal blood. But the concern here is that the oceans pH has now dropped to a pH of 8.1 and is continuing to fall.

The sea around Britain has been found to be more acidic than many other areas, partly because of ocean currents, but mainly because Europe and North America are the largest polluters of carbon dioxide! Experiments show that even a small increase in ocean acidity reduces the ability of shellfish and plankton to grow and the population to fall. The loss of coral would seriously affect small islands and coastal regions.

The fundamental problem is the effect on the food chain. Zooplankton, essential food for fish, could suffer increasing mortality rates and starfish, whelks and other shellfish, eaten by cod, might perish. This might lead to a population explosion of other creatures such as jellyfish, crabs, shrimp and lobsters which rely on chitin rather than sodium transformed to calcium for their shells.

The growing acidity of the ocean is highly distrubing to me, personally, because I believe that the human race is only as healthy as our oceans--just as the human cell is only as healthy as the alkaline water in which it is bathed. This problem is at the foundation of global warming as a symptom of our acidic oceans.

I appeal to you to share this email with everyone youknow, love, or care about. It is a matter of life and death of the planet and for you. It will take many sacrifices such as limiting the amount of time we drive our cars or fly on airplanes. But we all need to be aware of the problem and begin doing something about it.

A healthy life is all about the water, and the health of any animal or human is determined by maintaining the purity and akalinity of that water - first from without (our earthly oceans) and then from within (our bodily oceans).

On March 8th, the pH Miracle Center will be releasingour pH Miracle Water. This water is a structured alkaline water with a pH of 9.5 and an electrical potential of -250mV. This water is a natural spring water that containsover 87 trace minerals necessary to sustain life.

When you purchase pH Miracle Water, not only will yoube drinking what I believe to be the best water on the planet, but you will be contributing to the pH MiracleLiving Foundation, a non-profit organization dedicated to alkalizing our oceans, our planet and the animals and humans that live here.

For more information on the importance of the right kind of healthy alkaline water go to:
http://www.articlesofhealth.blogspot.com/ and
http://www.phmiracleliving.com/water.htm

To become a part of our healthy alkaline communitygo to:
http://www.phmiracleliving.com/
More aboutThe Growing Acidity of Our Oceans is a Threat to ALL Life on Earth!

The Stomach Secrets Bicarbonates To Alkalize the Food NOT Digest the Food Ingested!

Posted by luputtenan3 on Sunday, February 26, 2012


The following article is further evidence of Dr. Robert O. Young's research defining the true purpose of the stomach. Dr. Young suggests in his research that the stomach is designed to produce bicarbonates to buffer acids from diet and metabolism and NOT for the purpose of producing the acidic waste product hydrochloric acid (HCL) to digest food. Hydrochloric acid is a waste product of the stomach producing sodium bicarbonate to buffer the acids of what we eat, what we drink, what we think and how we live. The stomach is an alkalizing organ and NOT an organ of digestion. This is the NEW BIOLOGY and the new understanding of how the digestive system works - or better said how the alkaline buffering system works.

I perceive you understand, as I have, the increasing number of MAO (Monoamine Oxidase) Inhibitors that are flooding the market, and said to reduce Inflammation, which is getting the rap for everything from a runny nose to Alzheimer’s. MAOIs are classes of antidepressant drugs traditionally prescribed for the treatment of depression.

Most recently, I have noted a very large push by pharmaceutical companies hyping products like Anatabine Citrate, with claims such as: Anatabine Citrate is a dietary supplement for anti-inflammatory support of the immune system. Since many disorders, like coronary artery disease, diabetes, asthma, Alzheimer’s, and rheumatoid arthritis, are caused by chronic low-level inflammation, Anatabine Citrate is a potential preventative treatment for these diseases.

Anatabine Citrate is a Nitrogenous compound isolated from Tobacco and cigarette smoke and touted as an alternative to anti-smoking remedies. Maybe you can now smoke yourself to health?

I am always amused by the push by large pharmaceutical companies to come up with new “wonderful” drugs to sell the public at very inflated prices, as alternative to actions that can be taken almost for free, achieving much the same results with very common agents! Recently, there has been a huge push by the world’s pharmaceutical companies to Patent Ayurvedic remedies in India that have been everywhere available at very low cost for centuries. The pharmaceutical companies want Patent rights to these compounds so that they can charge exorbitant fees for products that for centuries have been very low cost.

Anyway, my delayed point is… there actually seems to be a huge benefit to be obtained from serious anti-inflammatory compounds to reduce low-level chronic inflammation or tissue acidosis that seems to come inexorably and increasingly with advancing age. Inflammation or tissue acidosis contributes to every type of age-related deterioration.

But… here is the punch line: One of the most effective Anti-inflammatory agents known to exist has been around for centuries, at very low cost, and…. it is our old friend the Bicarbonates!

There are a very large number of references to the Anti-inflammatory effects of Bicarbonates available by a simple Internet search, for examples:

http://www.ncbi.nlm.nih.gov/pubmed/313351

http://archinte.ama-assn.org/cgi/content/abstract/147/12/2093

http://gut.bmj.com/content/24/9/784.abstract

Why empty your wallet and break your bank to pay for extremely expensive “designer” pharmaceutical compounds to combat chronic acidic inflammation, when all you need are the common Bicarbonates, the most effective of which are found in Dr. Robert O Young's, Young pHorever pHour Salts. To learn more about pHour salts go to:

http://www.phmiracleliving.com/p-221-phour-salts.aspx

References:

1) Gastroenterology. 1979 Sep;77(3):451-7.

Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa.

Abstract

Effects of antiinflammatory agents and prostaglandins on H+ and HCO-3 secretions and electrical properties were investigated in the amphibian-isolated gastric mucosa. Gastric HCO-3 transport was studied in Rana temporaria fundus, in which H+ secretion had been inhibited with the histamine H2-receptor antagonists metiamide or cimetidine (10(-3) M), and in Necturus antrum, which secreted HCO-3 spontaneously. Hydrocortisone (100-500 microgram/ml) had no effect on H+ or HCO-3 secretion in the fundus. Indomethacin (10(-4) M) was a considerably more potent inhibitor of HCO-3 secretion than of H+ secretion in the fundus and also inhibited HCO-3 transport in the antrum. Fenclofenac (3 x 10(-3) M) almost abolished fundic HCO-3 transport and also depressed H+ secretion. There was a marked fall in transmucosal potential difference and a decrease in electrical resistance in fenclofenac-treated mucosae whereas indomethacin had less effect on electrical properties at the concentrations used here. The prostaglandins, E2, 16,16-dimethyl E2 and I2 all inhibited H+ secretion but only 16,16-dimethyl E2 stimulated HCO-3 secretion. The inhibitory action of indomethacin on HCO-3 secretion was prevented by co-administration of 16,16-dimethyl PGE2 (10(-6) M). It is proposed that the inhibitory action of nonsteroidal antiinflammatory drugs and the stimulatory action of some prostaglandins on HCO-3 secretion contributes to their ulcerogenic and anti-ulcer actions on the gastric mucosa.

PMID:
313351
[PubMed - indexed for MEDLINE]

2)
Nonsteroidal Anti-inflammatory Drug Gastropathy

Recognition and Response

Sanford H. Roth, MD; Ralph E. Bennett, MD

Arch Intern Med. 1987;147(12):2093-2100.


Abstract



• Gastropathy, recognized as gastric lesional disease ranging from erosions to actual ulcer craters, represents the most ubiquitous significant complication of common nonsteroidal anti-inflammatory drug (salicylate and nonsalicylate) use. Recently, this association has been established as distinct from classic peptic ulcer disease,which is primarily acidmediated, duodenal, and more prevalent in a younger, often male, population. Nonsteroidal anti-inflammatory drug gastropathy is usually antral/prepyloric disease, and research indicates it is mediated through blockade of cyclooxygenase with reduction in cytoprotective gastric prostaglandins. Theprevious literature has been confounded with short-term studies on healthy volunteers and animals that emphasize the resiliency of normal gastric adaptation to heal such gastropathy. Newer long-term studies in patients with arthritis undergoing anti-inflammatory therapy on a sustained basis indicate fatigue of normal adaptation,with persisting gastropathy leading to bleeding and even death. In addition, silent lesions are more common as symptomatology is not synchronous with lesional disease. Since endoscopy is an expensive, not always utilized procedure, it is important to identify the population most at risk for appropriate cytoprotectivemanagement as well as modification of the anti-inflammatory therapy program.

(Arch Intern Med 1987;147:2093-2100)


Author Affiliations



From the Arthritis Center Ltd/Arizona Institute, Phoenix.


Footnotes



Accepted for publication Aug 31, 1987.

Reprint requests to Arthritis Center Ltd/Arizona Institute, 3330 N Second St, Suite 601, Phoenix, AZ 85012 (Dr Roth).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Efficacy and Safety of a Topical Diclofenac Solution (Pennsaid) in the Treatment of Primary Osteoarthritis of the Knee: A Randomized, Double-Blind, Vehicle-Controlled Clinical Trial
Roth and Shainhouse
Arch Intern Med 2004;164:2017-2023.
ABSTRACT | FULL TEXT

Helicobacter pylori infection in rheumatoid arthritis: effect of drugs on prevalence and correlation with gastroduodenal lesions
Ishikawa et al.
Rheumatology (Oxford) 2002;41:72-77.
ABSTRACT | FULL TEXT

NSAID Gastropathy: A New Understanding
Roth
Arch Intern Med 1996;156:1623-1628.
ABSTRACT

Use of nonsteroidal anti-inflammatory drugs in cancer
Pace
Palliat Med 1995;9:273-286.
ABSTRACT

Corticosteroids and peptic ulceration
Ellershaw and Kelly
Palliat Med 1994;8:313-319.
ABSTRACT

Adverse Gastrointestinal Effects of Nonsteroidal Anti-Inflammatory Drugs
Erstad and Lipsy
Journal of Pharmacy Practice 1994;7:144-153.
ABSTRACT

Massive Gastrointestinal Bleeding Associated With Ketorolac Administration
Erstad and Neumayer
Journal of Pharmacy Practice 1992;5:xi-xii.

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis
Gabriel et al.
ANN INTERN MED 1991;115:787-796.
ABSTRACT

The Impact of Ulcerogenic Drugs on Surgery for the Treatment of Peptic Ulcer Disease
Bliss and Stabile
Arch Surg 1991;126:609-612.
ABSTRACT

The Cost-effectiveness of Misoprostol
Roth
JAMA 1991;265:593-594.
ABSTRACT

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug--Induced Gastrointestinal Tract Bleeding
Edelson et al.
JAMA 1990;264:41-47.
ABSTRACT

Nonsteroidal Anti-inflammatory Drug Nephrotoxicity: Should We Be Concerned?
Stillman and Schlesinger
Arch Intern Med 1990;150:268-270.
ABSTRACT

Economic Effects of Prophylactic Use of Misoprostol to Prevent Gastric Ulcer in Patients Taking Nonsteroidal Anti-inflammatory Drugs
Hillman and Bloom
Arch Intern Med 1989;149:2061-2065.
ABSTRACT

Misoprostol Heals Gastroduodenal Injury in Patients With Rheumatoid Arthritis Receiving Aspirin
Roth et al.
Arch Intern Med 1989;149:775-779.
ABSTRACT

Therapeutic Drug Monitoring in Patients With Ulcers
Itokazu and Danziger
Journal of Pharmacy Practice 1989;2:382-392.

Nonsteroidal Anti-Inflammatory Drugs: Gastropathy, Deaths, and Medical Practice
Roth
ANN INTERN MED 1988;109:353-354.
ABSTRACT

Antiulcer Therapy in Nsaid Gastropathy: A Rheumatologist's Perspective
Roth
Drug Information Journal 1988;22:419-424.
ABSTRACT

NSAIDs: Risk-Benefit versus Cost-Benefit
Roth
Drug Information Journal 1988;22:477-481.
ABSTRACT

3) Gut 1983;24:784-789 doi:10.1136/gut.24.9.784

  • Articles

Effects of non-steroidal anti-inflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro

Abstract

The effects of non-steroidal anti-inflammatory drugs and prostaglandins E2 and F on the secretory and electrical activity of isolated rabbit fundic mucosa have been studied. Spontaneous acid secretion was inhibited by serosal side application of sodium thiocyanate (6×10−2M) and the resulting alkali secretion measured by pH stat tiration. Serosal side application of indomethacin (10−5M) or aspirin (3×10−3M) inhibited alkali secretion (0·55±0·06 to 0·12±0·06 μmol/cm2/h, n=6, p<0·01 and 0·28±0·06 to 0·11±0·03 μmol/cm2/h, n=7, p<0·02 respectively). Mucosal or serosal side prostaglandin E2 (10−5 to 10−10M) and F(10−4 to 10−10M) failed to alter the rate of alkalinisation but secretion was significantly increased by serosal side 16,16-dimethyl-prostaglandin E2 (10−6M) (0·90±0·20 to 1·50±0·30 μmol/cm2/h, n=6, p<0·01). Serosal side application of 10−6M prostaglandin E2 to fundic mucosae pretreated with either aspirin (5×10−3M) or indomethacin (10−5M), to reduce endogenous E2 formation, also failed to alter alkali secretion. Pretreatment of the mucosa with 16,16-dimethyl-E2 (10−6M) abolished the inhibitory effect of indomethacin (10−5M) on alkali secretion (n=6) but did not modify the secretory response to aspirin (3×10−3M) (fall in alkali secretion with aspirin = 81±11% and with aspirin plus 16,16-dimethyl-E2 = 72±10%, n=7). In the doses used, none of the prostaglandins or non-steroidal anti-inflammatory drugs altered transmucosal potential difference or electrical resistance. These results show that the damaging agents, aspirin and indomethacin, both inhibit gastric alkali secretion but that modes of action may differ. The observation that prostaglandins, E2 and F failed to increase alkali production suggests that their protective activity against a variety of damaging agents as shown by others, may be mediated by another mechanism.

More aboutThe Stomach Secrets Bicarbonates To Alkalize the Food NOT Digest the Food Ingested!